The challenges for Newcastle don’t get any easier however, as the Magpies travel to a stadium where they have never tasted victory in the Premier League.
Their clash with Manchester City at the Etihad Stadium is also one that could have huge ramifications for the title race and their battle to qualify in a Champions League spot this season.
But what starting XI will Howe pick for the game with the reigning Premier League champions? Will Nick Pope come straight back into the team? How will Newcastle cope if Bruno Guimaraes is injured?
Here, we take a look at the starting side Howe could pick for the trip to the Etihad Stadium. Do you agree with our picks? Follow us on our social media channels and let us know your thoughts there.
But what starting XI will Howe pick for the game with the reigning Premier League champions? Will Nick Pope come straight back into the team? How will Newcastle cope if Bruno Guimaraes is injured?
5. Sven Botman
One of Botman’s first experiences of Premier League football came against Manchester City back in August and although they conceded three that afternoon, the Dutchman put in a solid performance on his full St James’ Park debut. Photo: George Wood
6. Dan Burn
There have been calls for Matt Targett to come into the back-four this weekend, however, Burn will feel his form this season has earned him an opportunity to impress on Saturday. Newcastle will likely be on the back-foot this weekend and will need their back-four, that have played together a lot this season, to be on top form. Photo: George Wood
7. Bruno Guimaraes
The Brazilian was substituted during the game with Manchester United on Sunday but has been pictured in training this week. Newcastle haven't won a league game in his absence this season and it will be fantastic to see him back in the starting XI. Photo: Eddie Keogh
8. Sean Longstaff
Longstaff played just 45 minutes of the Carabao Cup final and will be hoping to impress this weekend. The midfield three has been a fairly settled unit this season and Longstaff is a vital part of the trio. Photo: George Wood