The challenges for Newcastle don’t get any easier however, as the Magpies travel to a stadium where they have never tasted victory in the Premier League.
Their clash with Manchester City at the Etihad Stadium is also one that could have huge ramifications for the title race and their battle to qualify in a Champions League spot this season.
But what starting XI will Howe pick for the game with the reigning Premier League champions? Will Nick Pope come straight back into the team? How will Newcastle cope if Bruno Guimaraes is injured?
Here, we take a look at the starting side Howe could pick for the trip to the Etihad Stadium. Do you agree with our picks? Follow us on our social media channels and let us know your thoughts there.
9. Joelinton
The Brazilian was very impressive against Guardiola’s side in August. Used in a role to disrupt Manchester City’s play on that occasion, it’s likely he will operate in a similar role this time around. Photo: Julian Finney
10. Miguel Almiron
Almiron opened his account for the season in the first meeting and will be hoping to add to his ten strikes this weekend. He has stated that Jack Grealish’s comments at the end of last season haven’t affected his performances this campaign. Photo: ADRIAN DENNIS
11. Alexander Isak
If Isak can repeat his performance from their game at Anfield earlier in the campaign, then he may be a great option for Newcastle this weekend. His work off the ball is fantastic and his athleticism could be a real weapon when they are afforded the opportunity to counter-attack. Photo: ADRIAN DENNIS
12. Allan Saint-Maximin
Although Anthony Gordon will be itching to start, Saint-Maximin showed in August just how much he can trouble this City defence. The Frenchman was a menace throughout that game and Kyle Walker will still be having nightmares over potentially having to mark Saint-Maximin again this weekend. Photo: Julian Finney