A Ben White own goal and a late strike from Bruno Guimaraes were enough to secure three points against the top four chasing Gunners.
For Targett, it would potentially be his last game at St James’s Park as a Newcastle player with his loan from Aston Villa set to expire at the end of the season.
But Newcastle do have a £15million option to buy the left-back from their Premier League rivals, something Guimaraes made clear he wants the club to trigger.
Newcastle United consider loan for £58m 'captain' as Chelsea trio remain on Eddie Howe's radar
Goncalo Ramos' 14-word response to Newcastle United transfer interest following ‘bid’ reports
Brendan Rodgers reveals he talked Swansea City defender out of move to Newcastle United whilst on Mount Kilimanjaro
Chelsea ‘considering second bid’ for Newcastle United target, Southampton forward ‘top’ of Everton wanted list
Sergio Aguero backs 'difficult' Newcastle United, Aston Villa and Brighton to ‘fight’ for Europe
The Brazilian interrupted Targett’s interview with NUFC TV to state: “He needs to stay,” while pointing at the January loan arrival.
Targett, who was serenaded by the home supporters following the match, then took to Instagram as he posted: “Last game at St James’s Park and what a game it was. Atmosphere was electric once again! One more to go.”
Newcastle face Burnley in their final match of the season this weekend as they look to end a memorable season on a high.
For Targett, it could be his final game for United in what has been a memorable loan spell to help the club secure Premier League survival.
And former Villa player Gabby Agbonlahor was quick to remind Targett that his time on Tyneside is in fact coming to an end.
He responded to the 26-year-old’s Instagram post with the message: “Don’t get comfortable! [You’re] a Villa player!”