But who replaces the talismanic frontman this evening for the visit of the newly-crowned top flight champions?
Our Newcastle United writer Liam Kennedy takes a look at the side he would pick – and it not only includes a change up top to make up for the absence of Wilson, but also sees a little reshuffle further back.
5. Paul Dummett
Bagged his first goal since 2016 at the King Power Stadium and put in a solid show defensively. Has been a key, calming influence in the recent upturn in fortunes.
Photo: ALEX PANTLING
6. Matt Ritchie
Enthusiasm knows no bounds. And if this is his NUFC swansong, he's played a considerable role in retaining the club's Premier League status - even if he didn't think he would.
Photo: MICHAEL REGAN
7. Sean Longstaff
Wasn't happy that he was dropped, and the manner in which he was told, so will be keen to return to the starting XI again. And his form suggests he should. Replaces Jonjo Shelvey, for me, with Ritchie taking the armband.
Photo: Clive Brunskill
8. Joe Willock
Goals galore and an amazing engine. The lad looks a real talent, and one United should look to snap up, any which way, in the summer window.