Eddie Howe will be without several key players for the trip to Craven Cottage with late calls to be made on others.
Meanwhile, Fulham head coach Marco Silva will also be without a number of first-team players.
Newcastle are set to welcome Callum Wilson and Elliot Anderson from their respective hamstring injuries while Bruno Guimaraes is expected to be involved after experiencing an injury scare with Brazil during the international break.
Fulham frontman Aleksandar Mitrovic also suffered a slight knock while away on international duty with Serbia but he looks likely to be involved against his former club this weekend.
Here are the players who are doubts and those who have been ruled out for both Newcastle and Fulham this weekend...
5. NUFC: Alexander Isak - OUT
The striker withdrew from the Sweden squad due to a leg injury injury. It was enough to keep him out of Sweden’s next two Nations League matches and he was assessed on his return to Newcastle. Although his injury isn’t thought to be serious, he will sit this match out. Photo: George Wood
6. NUFC: Chris Wood - DOUBT
Another Newcastle striker who could miss Saturday’s match is Chris Wood. The New Zealand international suffered a rib injury during the All Whites’ match against Australia last week. Newcastle head coach Eddie Howe has said a late call will be made regarding whether he makes the squad on Saturday. | Getty Images
7. NUFC: Allan Saint-Maximin - DOUBT
Newcastle have missed the winger in the past three Premier League games but he is closing in on a return from a hamstring injury. Speaking ahead of Saturday’s game, Howe said Saint-Maximin was ‘very close’ to a return but couldn’t provide complete clarity on whether he’d be involved. | Getty Images
8. NUFC: Matt Ritchie - DOUBT
The 33-year-old picked up a calf injury in training and is unlikely to make the trip to Craven Cottage though his injury is not thought to be serious. Photo: Stu Forster