Eddie Howe will be without several key players for the trip to Craven Cottage with late calls to be made on others.
Meanwhile, Fulham head coach Marco Silva will also be without a number of first-team players.
Newcastle are set to welcome Callum Wilson and Elliot Anderson from their respective hamstring injuries while Bruno Guimaraes is expected to be involved after experiencing an injury scare with Brazil during the international break.
Fulham frontman Aleksandar Mitrovic also suffered a slight knock while away on international duty with Serbia but he looks likely to be involved against his former club this weekend.
Here are the players who are doubts and those who have been ruled out for both Newcastle and Fulham this weekend...
9. NUFC: Jonjo Shelvey - OUT
The midfielder is close to returning from a serious hamstring injury sooner than expected but this weekend’s match comes just too early. Photo: Gualter Fatia
10. NUFC: Karl Darlow - OUT
Darlow is facing an extended spell on the sidelines with an ankle injury. Newcastle signed Loris Karius as a free agent as a result. Photo: Gualter Fatia
11. NUFC: Emil Krafth - OUT
The right-back will be hoping to feature for Newcastle before the end of the season after suffering a serious knee injury against Tranmere Rovers in the Carabao Cup in August. | Getty Images