A 2-0 victory against the Hammers during last season’s opener provided plenty of optimism for Magpies fans before it all descended into a relegation battle.
Steve Bruce’s side will be hoping the upcoming term fetches better times ahead and that they won’t have to worry about the prospect of dropping into the Championship.
But are the bookmakers backing United to retain their top-flight status once more?
Here are the latest relegation odds for every Premier League club via SkyBet:
5. Tottenham Hotspur - 66/1
It’s going to be an interesting few months at Spurs as they look to appoint a new manager. There is, of course, Harry Kane’s transfer saga to come.
Photo: Shaun Botterill
6. Arsenal - 50/1
Mikel Arteta’s men want to achieve European qualification again after missing out last season in 8th.
7. Leicester City - 40/1
The FA Cup winners will play Europa League football next season after surrendering their Champions League spot.
Photo: Laurence Griffiths
8. Everton - 20/1
A big summer for Everton following the shock departure of Carlo Ancelotti to Real Madrid. Who will replace the Italian?