A 2-0 victory against the Hammers during last season’s opener provided plenty of optimism for Magpies fans before it all descended into a relegation battle.
Steve Bruce’s side will be hoping the upcoming term fetches better times ahead and that they won’t have to worry about the prospect of dropping into the Championship.
But are the bookmakers backing United to retain their top-flight status once more?
Here are the latest relegation odds for every Premier League club via SkyBet:
17. Crystal Palace - 9/4
How will Palace fare without Roy Hodgson? There is that, and also the majority of their playing squad being out-of-contract. A big summer ahead. Photo: Henry Browne
18. Brentford - 11/10
Brentford are preparing for a debut season in the Premier League after beating Swansea City 2-0 in the Championship play-off final. Photo: Catherine Ivill
19. Watford - 1/1
Back in the big time after one season away. The Hornets return with Xisco Munoz at the helm. Photo: Richard Heathcote
20. Norwich City - 10/11
The Canaries stuck by Daniel Farke following their Premier League relegation a year ago and their faith was repaid after lifting the Championship title. Photo: George Wood