The Magpies have a largely solid record against the Blues at home in recent years, and will be hopeful of securing another positive results against the Blues in front of a packed stadium once again.
Meanwhile, the club continue to search for a successor to Steve Bruce, as they look to find the right candidate to take them into the new era following the big-money takeover.
Discussing the options open to the Magpies, talkSPORT pundit Simon Jordan said: “This football club is going to be an opportunity for someone, it’s when you take that opportunity.
“And I just think the sensible thing for Newcastle would be to some way or another, find an interim appointment until they work out who they are, what they are and get a clean slate.
“Now, you have got to try and find a way to stay in the division and that to me feels like a job for someone who knows how to do that and then build on that platform with somebody who comes in that’s an elite manage and give him the embarrassment of riches he would be entitled to.”
The likes of ex-Roma boss Paulo Fonseca, former Borussia Dortmund manager Lucien Favre, and 47-year-old Leonardo Jardim are believed to be the current front-runners for the position.
Here is our rundown of the latest news and updates from the Premier League, as the build-up to this weekend's eagerly-anticipated action continues:
1. £34m could land Lang
Leeds United, West Ham and Arsenal-linked forward Noa Lang is said to be valued at around £34m by Club Brugge, who are keen to ward off interest in their star man in January. The ex-Ajax starlet has scored three goals an made five assists in the league so far this season. (Express) Photo: TOM GOYVAERTS
2. Diallo eyes loan move
Manchester United youngster Amad Diallo is believed to be interested in a potential loan move to Feyenoord, according to reports from the Netherlands. The youngster joined the Red Devils for £37m back in January, but he's featured sparingly since joining from the club. (Sport Witness) Photo: PAUL ELLIS
3. Foxes target could cost big money
Leicester City face the prospect of having to shell out around €40m if they're to have any hope of signing Angers wonderkid Mohamed-Ali Cho, who continues to impress in Ligue 1. He began his career on the book of PSG's youth academy. (Leicester Mercury) Photo: JEAN-FRANCOIS MONIER
4. City wanted Chelsea star
Man City reportedly made a move to sign Belgian striker Romelu Lukaku last year, but the Citizen's focus on Harry Kane and Lukaku's desire to win Serie A with Inter saw the move break down. He completed a £97m back to Chelsea instead last summer. (Telegraph) Photo: BEN STANSALL