It's a bit of a free hit for both sides, with the Blades already relegated, and the Magpies safe from the drop with time to spare after a strong tail-end of the season from Steve Bruce's side.
Speaking ahead of the game, defender Paul Dummett, whose contract is set to expire next month, was quizzed on whether he'll extend his stay with Newcastle, and said: “Hopefully I’ll make my 200th appearance on Wednesday but I’m hoping to add as many more as I can.
“I’ve been at the club for a long time now, so hopefully I can extend my stay and keep on creeping up with those appearances.
“If you had told me as a young kid I’d be playing 200 games for Newcastle, I would have snapped your hand off. To hopefully do it on Wednesday night will be a great achievement for the family and I.
“It’s something I’ve worked really hard for and hopefully there will be many more to come in the future.”
Meanwhile, Bruce has insisted his side will be looking to maintain their winning attitude ahead of tonight's game against the Blades, with a strong focus on putting on a show for fans returning to St James' Park.
Here are today's biggest transfer stories and the latest team news involving Newcastle United and the rest of the Premier League, as the build-up to this weekend's action begins:
1. Arsenal loans star hints at stay
Arsenal loanee Martin Odegaard has claimed he's "happy" at the club, but is yet to discover Real Madrid's plans for him. Reports earlier in the year suggested Los Blancos would demand a hefty £52m for the Norway skipper. (Football London) Photo: Dan Mullan
2. Dyche among favourites for Palace job
Burnley boss Sean Dyche is among the favourites to become the next Crystal Palace, alongside Frank Lampard and Swansea's Steve Cooper. However, the Clarets manager is set for contract talks with his current club at the end of the season. (Oddschecker) Photo: MARTIN RICKETT
3. Moyes to seal new deal
West Ham United are set to announce the extension of manager David Moyes' contract next week. The Scotsman has revived his career with the Hammers, who are track to qualify for next season's Europa League. (Evening Standard) Photo: Warren Little
4. Pundit makes Kane claim
Football pundit Frank McAvennie has claimed that Spurs' Harry Kane is aware of who the club's new permanent manager, and that this played a part in his decision to leave the club. He could cost a whopping £150m, with Man City, Man Utd and Chelsea all keen. (Football Insider) Photo: ANDREW COULDRIDGE