It's a bit of a free hit for both sides, with the Blades already relegated, and the Magpies safe from the drop with time to spare after a strong tail-end of the season from Steve Bruce's side.
Speaking ahead of the game, defender Paul Dummett, whose contract is set to expire next month, was quizzed on whether he'll extend his stay with Newcastle, and said: “Hopefully I’ll make my 200th appearance on Wednesday but I’m hoping to add as many more as I can.
“I’ve been at the club for a long time now, so hopefully I can extend my stay and keep on creeping up with those appearances.
“If you had told me as a young kid I’d be playing 200 games for Newcastle, I would have snapped your hand off. To hopefully do it on Wednesday night will be a great achievement for the family and I.
“It’s something I’ve worked really hard for and hopefully there will be many more to come in the future.”
Meanwhile, Bruce has insisted his side will be looking to maintain their winning attitude ahead of tonight's game against the Blades, with a strong focus on putting on a show for fans returning to St James' Park.
Here are today's biggest transfer stories and the latest team news involving Newcastle United and the rest of the Premier League, as the build-up to this weekend's action begins:
5. Blades linked with Russell
Sheffield United and Fulham have both been credited with an interest in Kansas City forward Johnny Russell. The Scotland international has been playing out in the MLS since 2018, but could leave on the cheap before his contract expires in October. (The Sun) Photo: Ed Zurga
6. Brighton target wants to stay in England
Brighton hopes of signing Galatasaray striker Mbaye Diagne, currently on loan at West Brom, look to have been boosted, with the £8m-rated ace keen to remain in England. However, Watford and Crystal Palace are also keen on the Senegalese international. (Aspor) Photo: Shaun Botterill
7. Whites tipped to land Cunha
Leeds United are the fresh favourites to sign Hoffenheim's £25m-rated star Matheus Cunha, ahead of the likes of Monaco and Napoli. The Brazil international has scored seven goals and made four assists in the Bundesliga this season. (SkyBet) Photo: Alexandre Schneider
8. Bamford named as potential Kane replacement
Leeds United striker Patrick Bamford has been tipped a possible replacement for Harry Kane at Spurs, alongside the likes of Brentford's Ivan Toney and Southampton's Danny Ings who are set to be in high demand this summer. (Daily Mail) Photo: Pool