The Red Devils, who now has superstar Cristiano Ronaldo back among their ranks, will be pushing for the title this season, and the Magpies will need to be at their best to secure a positive result against the hosts.
Meanwhile, Newcastle talisman Allan Saint-Maximin has opened up on why he opted to remain at the club despite having the potential to leave the club for a hefty fee in the last transfer window. He revealed: “I’ve got a really good connection (with the fans). That’s why I decided to stay at Newcastle.
“For the love and the support they give me, it’s so important for me and they deserve more. Last season, it was a long time without supporters so every goal I scored I could not celebrate with them.”
He added: “It’s difficult when you feel everything is against you. We have conceded three penalties (so far this season). It’s hard but sometimes this happens and it’s better to happen at the start of the season.
“Everyone feels good because we know how hard we work in training. I feel really tired because we are working a lot. We just have to keep going, even if things go against us.
“We have to keep our head up because if the head goes down, it’s more difficult for everyone.”
Take a look at the latest news round-up from the Premier League, as the build-up to the weekend's action continues:
1. Wolves target set to leave in January
Wolves target Duje Caleta-Car looks set to be sold by Marseille in January. He's believed to have snubbed both Wolves and Valencia in the last transfer window, but the Ligue 1 side are still keen to move on the Croatia international. (L'Equipe) Photo: LAURENCE GRIFFITHS
2. Villa ready January raid for McKennie
Aston Villa have been tipped to make a January swoop for Juventus midfielder Weston McKennie, but they could face competition from fellow Premier League side Spurs. The former Schalke sensation is likely to cost around £25m. (Calciomercato) Photo: PAU BARRENA
3. Duo linked with Pedri
Liverpool and Manchester City have been named as two leading candidates to sign Barcelona sensation Pedri in the summer. The midfield ace, who lit up Euro 2020 with Spain, could be sold for a fee in the region of £85m. (Sport Witness) Photo: JOSEP LAGO
4. Man Utd bring in Covid-19 spot checks
Manchester United have confirmed they will become the latest club to introduce Covid-19 spot checks at home games, with the system set to become mandatory at the start of next month. Brighton, Chelsea and Spurs already have Covid-19 vaccination checks in place. (BBC Sport) Photo: Michael Regan