The Hammers will go into the weekend’s round of fixtures just one point above the relegation zone and could even begin Saturday evening’s game in the drop-zone.
Newcastle, meanwhile, are sitting pretty in 3rd place and aiming to extend their unbeaten Premier League run to 16 games when they host David Moyes’s side.
However, the Magpies will be without key man Bruno Guimaraes following his red card against the Saints and could be without Alexander Isak as well after he left the pitch with a head-injury on Tuesday night.
So how will Eddie Howe react to these setbacks and what side will he pick on Saturday?
Here, we take a look at the Newcastle United starting XI that Howe could pick to face West Ham.
Do you agree with our picks? Follow our social media channels and let us know your thoughts there.
5. CB: Sven Botman
Botman is getting more and more accustomed to the demands of Premier League football every week and is becoming a true Rolls Royce of a defender. Photo: PAUL ELLIS
6. LB: Dan Burn
Burn may be off to get his suit measured, but the focus this weekend returns to the league and Newcastle have a great opportunity to strengthen their claim for a top four place. Photo: Stu Forster
7. CM: Joe Willock
Willock has featured in central midfield and on the wing recently but because of Bruno Guimaraes’s suspension, he will likely be asked to move into the middle of the park this weekend. Photo: Gareth Copley
8. CM: Sean Longstaff
A midweek brace from Longstaff against Southampton secured the Magpies their passage to Wembley. He may be required to play a slightly deeper role against Southampton however. Photo: Stu Forster