The Hammers will go into the weekend’s round of fixtures just one point above the relegation zone and could even begin Saturday evening’s game in the drop-zone.
Newcastle, meanwhile, are sitting pretty in 3rd place and aiming to extend their unbeaten Premier League run to 16 games when they host David Moyes’s side.
However, the Magpies will be without key man Bruno Guimaraes following his red card against the Saints and could be without Alexander Isak as well after he left the pitch with a head-injury on Tuesday night.
So how will Eddie Howe react to these setbacks and what side will he pick on Saturday?
Here, we take a look at the Newcastle United starting XI that Howe could pick to face West Ham.
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9. CM: Joelinton
Joelinton has been superb in midfield for a long, long time with very few Newcastle fans genuinely able to name the last time he had a poor performance in the black and white. Photo: Gareth Copley
10. RW: Miguel Almiron
Despite not scoring too often recently, Almiron remains an integral part to this side and secured a great assist for Longstaff’s second goal in midweek. Photo: PAUL ELLIS
11. ST: Callum Wilson
Alexander Isak has been breathing down Wilson’s neck but a potential concussion could rule the Swede out of Saturday’s match. Wilson has endured a goal scoring drought of late and will want to end that against the Hammers. Photo: Stu Forster
12. LW: Allan Saint-Maximin
Fans will be eagerly-anticipating Anthony Gordon’s Newcastle United debut, but Howe may feel the need to introduce him to the side slowly. That could give Saint-Maximin a golden opportunity to stake his claim for a first-team spot. Photo: Gareth Copley