Last time out, Steve Bruce changed formation from 5-3-2 to 4-3-3 as his side drew 1-1 at Watford.
The Magpies, who took the lead through Sean Longstaff, squandered numerous chances to win the game before Ismaila Sarr equalised on 73 minutes.
It is likely Bruce will stick with the system – but which players will he turn to at Molineux? Here's our predicted starting XI.
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5. LB: Matt Ritchie
Left-back isn’t Ritchie’s natural position as such. He can often get caught out defensively but his deliveries into the box are a real asset. Photo: Stephen Pond
6. CM: Isaac Hayden
Having started in a three-man central defence against Manchester United and Leeds, Hayden returned to the midfield at Watford. Photo: Alex Morton
7. CM: Sean Longstaff
Longstaff’s upturn in form at Newcastle hasn’t gone unnoticed - capping off a fine few weeks with a stunning goal at Watford. Photo: Alex Morton
8. CM: Joe Willock
Willock was a surprise starter at Watford given Bruce had ruled him out 24 hours prior. Hopefully, his foot injury is manageable. Photo: Alex Morton