Last time out, Steve Bruce changed formation from 5-3-2 to 4-3-3 as his side drew 1-1 at Watford.
The Magpies, who took the lead through Sean Longstaff, squandered numerous chances to win the game before Ismaila Sarr equalised on 73 minutes.
It is likely Bruce will stick with the system – but which players will he turn to at Molineux? Here's our predicted starting XI.
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9. RW: Miguel Almiron
A much-needed change in position for Almiron after he became a little lost in his central midfield role in the 5-3-2 system. Photo: Stephen Pond
10. LW: Joelinton
While goals continue to evade United’s record signing, his physicality has been a real strong point in recent weeks. Photo: Ian MacNicol
11. ST: Allan Saint-Maximin
Saint-Maximin is not an out-and-out striker but it’s working at the moment. The Frenchman's pace, power and ability to find pockets of space is beyond crucial to Newcastle’s success. Photo: Stephen Pond