A win could see them strengthen their claims on a top flight, top 10 finish, while also plunging the Hammers back into the relegation quagmire.
But who will get the nod, with injuries aplenty, and who will miss out?
Here we take a look at Steve Bruce’s likely starting XI for the visit of David Moyes’ men, as changes are expected.
5. LEFT-BACK: Danny Rose
The left-back is likely to replace Javier Manquillo this afternoon after a midweek break. Is he slowly playing his way into a permanent deal? Photo: Pool
6. CENTRAL MIDFIELD: Isaac Hayden
Likely to get the nod over Nabil Bentaleb in the middle as Steve Bruce shuffles his pack. And he'll be keen to forget about that miss on Wednesday!?! Photo: Pool
7. CENTRAL MIDFIELD: Jonjo Shelvey
Will want to impress against the team he supports - and who are forever linked with a move! Photo: PETER CZIBORRA
8. RIGHT WING: Matt Ritchie
Left out against his former club on Wednesday, the ex-Scotland international is likely to be thrown back in against the Hammers. He's certainly had his shooting boots on this season. Photo: Michael Steele