A win could see them strengthen their claims on a top flight, top 10 finish, while also plunging the Hammers back into the relegation quagmire.
But who will get the nod, with injuries aplenty, and who will miss out?
Here we take a look at Steve Bruce’s likely starting XI for the visit of David Moyes’ men, as changes are expected.
9. No10: Miguel Almiron
Seven goals for the season now for United's top-scorer Almiron. Another one off the bench in the week underlines how crucial a player he's been for Newcastle this season. Photo: GLYN KIRK
10. LEFT WING: Allan Saint-Maximin
At the moment he's absolutely unplayable. Skill, pace and end product - what more could you want? Photo: Pool
11. STRIKER: Andy Carroll
Surely it's only a matter of time isn't it? Andy Carroll to get off the mark... against his old club? Photo: MICHAEL STEELE
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