Newcastle United’s last 10 victories against Monday night’s opponents span 32 years with some of the winning goals in that time being scored by Glenn Roeder, Alan Shearer and Matty Longstaff.
Newcastle have had some recent ‘success’ in this fixture with two wins from their last four encounters at St James’s Park, however, historically they have not fared too well against the Red Devil’s.
On Monday night, Eddie Howe’s side will hope to put the demons of these defeats to bed and secure an unlikely win against Ralf Rangnick’s side – can they use their previous victories to inspire them?
Here, we take a look at the last ten times Newcastle United have defeated Manchester United:
What are your memories of these games? Follow us on Twitter @MouthofTynePod and let us know there.
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. NEWCASTLE, UNITED KINGDOM - OCTOBER 20: Newcastle strikers Alan Shearer (l) and Les Ferdinand celebrate a goal during the Premiership match between Newcastle United and Manchester United at St Jame's Park on October 20, 1996 in Newcastle, England. Newcastle won the game 5-0. (Photo by Ben Radford/Allsport UK/Getty Images)
Newcastle United victories against Manchester United don't come around often, but they tend to be memorable when they do (Photo by Ben Radford/Allsport UK/Getty Images) Photo: Ben Radford

. 6th October 2019: Newcastle United 1 - 0 Manchester United
The last time Newcastle defeated Manchester United came just shy of two years ago, courtesy of that Matty Longstaff goal. The game will probably be most remembered for the winning goal and the post-match interview between the two Longstaff brothers who started their first ever Premier League game together. (Photo by Ian MacNicol/Getty Images) Photo: Ian MacNicol

5. 15 September 2001: Newcastle United 4 - 3 Manchester United
On what was Sir Bobby Robson’s 100th game in charge of Newcastle, Laurent Robert’s superb free-kick kick-started a memorable day at St James’s Park. After being 3-1 ahead, it looked like Newcastle had thrown the game away but a Wes Brown own-goal saw the Toon run out winners. Oh and that Roy Keane red-card also happened. (Mandatory Credit: Gary M Prior /Allsport) Photo: Gary M. Prior

6. 12 February 2000: Newcastle United 3 - 0 Newcastle United
A superb Duncan Ferguson volley was supported by a brace from Alan Shearer as Newcastle defeated a Manchester United side that had beaten them at Wembley in the FA Cup final just eight-months previous. (Mandatory Credit: Shaun Botterill /Allsport) Photo: Shaun Botterill

7. 20 October 1996: Newcastle United 5 - 0 Manchester United
“On a day where Newcastle would have taken one-nil, here they are looking for number five with Phillipe Albert ooohh, absolutely glorious.” - Howay 5-0. (Photo by Stu Forster/Allsport/Getty Images) Photo: Stu Forster

8. 26 October 1994: Newcastle United 2 - 0 Manchester United
The visitors played eight teenagers for this Coca Cola cup tie and almost grabbed a draw, however, Phillipe Albert’s header, his first goal for Newcastle and a Paul Kitson goal late in the day was enough to secure Kevin Keegan’s side passage into the next round. (Mandatory Credit: Mike Hewitt/ALLSPORT) Photo: Mike Hewitt