Newcastle United’s last 10 victories against Monday night’s opponents span 32 years with some of the winning goals in that time being scored by Glenn Roeder, Alan Shearer and Matty Longstaff.
Newcastle have had some recent ‘success’ in this fixture with two wins from their last four encounters at St James’s Park, however, historically they have not fared too well against the Red Devil’s.
On Monday night, Eddie Howe’s side will hope to put the demons of these defeats to bed and secure an unlikely win against Ralf Rangnick’s side – can they use their previous victories to inspire them?
Here, we take a look at the last ten times Newcastle United have defeated Manchester United:
What are your memories of these games? Follow us on Twitter @MouthofTynePod and let us know there.
A message from the Football Clubs Editor
Our aim is to provide you with the best, most up-to-date and most informative Newcastle United coverage 365 days a year.
This depth of coverage costs, so to help us maintain the high-quality reporting that you are used to, please consider taking out a subscription; sign up here.
Your support is much appreciated. Richard Mennear, Football Clubs Editor

. NEWCASTLE, UNITED KINGDOM - OCTOBER 20: Newcastle strikers Alan Shearer (l) and Les Ferdinand celebrate a goal during the Premiership match between Newcastle United and Manchester United at St Jame's Park on October 20, 1996 in Newcastle, England. Newcastle won the game 5-0. (Photo by Ben Radford/Allsport UK/Getty Images)
Newcastle United victories against Manchester United don't come around often, but they tend to be memorable when they do (Photo by Ben Radford/Allsport UK/Getty Images) Photo: Ben Radford

. 6th October 2019: Newcastle United 1 - 0 Manchester United
The last time Newcastle defeated Manchester United came just shy of two years ago, courtesy of that Matty Longstaff goal. The game will probably be most remembered for the winning goal and the post-match interview between the two Longstaff brothers who started their first ever Premier League game together. (Photo by Ian MacNicol/Getty Images) Photo: Ian MacNicol

9. 26 December 1987: Newcastle United 1 - 0 Manchester United
Boxing Day 1987 was a memorable one for Newcastle United as a solitary goal from the late-Glenn Roeder was enough to secure the Toon a win. As half-time beckoned, Paul Gascoigne’s free-kick pinballed in the area before it was slammed home by Roeder. (Photo Allsport/Getty Images) Photo: Getty Images

10. 18 April 1987: Newcastle United 2 - 1 Manchester United
A strong challenge by Norman Whiteside on John Anderson, which was followed up by Peter Jackson’s retaliation on Whiteside started a feisty encounter at St James’s Park. Roeder’s towering header was cancelled out by a fantastic strike by Gordon Strachan before Paul Goddard poked home the winner to send the Gallowgate into raptures. (Photo by Pascal Rondeau/Allsport/Getty Images) Photo: Getty Images