With Callum Wilson already out of action, and with the gap between themselves and the relegation zone at just three points, the news that Allan Saint-Maximin and Miguel Almiron are both set to be sidelined until at April could be a hammer blow for the Magpies’ survival hopes.
Aside from that trio, Jeff Hendrick is the only Toon player to have scored more than one goal in the league this season.
Currently, Newcastle have seven players out injured – the joint-fourth-highest tally in the Premier League – but how have their fared over the course of the entire season compared to their top flight rivals?
We’ve taken a look at the total number of matches that players at each Premier League club have missed this term to determine who’s really had the worst luck in 2020/21…
*All data courtesy of Transfermarkt.
9. Sheffield United
Total matches missed: 88 Players injured: 13 Longest absence: Jack O'Connell (Photo by Shaun Botterill/Getty Images) Photo: Shaun Botterill
10. Leicester City
Total matches missed: 93 Players injured: 13 Longest absence: Ricardo Pereira (Photo by Tim Keeton - Pool/Getty Images) Photo: Pool
11. Wolves
Total matches missed: 99 Players injured: 11 Longest absence: Jonny Otto (Photo by JUSTIN TALLIS/POOL/AFP via Getty Images) Photo: JUSTIN TALLIS
12. Arsenal
Total matches missed: 101 Players injured: 19 Longest absence: Pablo Mari (Photo by Michael Regan/Getty Images) Photo: Michael Regan