Newcastle had a goal ruled out from Joelinton for handbal in the first half. The Brazilian then missed a sitter early in the second half as the game remained goalless.
But it would prove to be third time lucky for Joelinton as he turned the ball in from close range following some great work down the right from Alexander Isak to set up the goal.
A minute later Southampton thought they’d equalised as former Magpies striker Adam Armstrong bundled the ball into the net only for it to be ruled out for handball following a VAR check.
Southampton were reduced to 10 men late on as Duje Caleta-Car was shown a second yellow card.
Here are the Newcastle player ratings from the match...