Wilson, United’s top scorer this season with 10 goals, missed seven matches between February and early April with a hamstring injury sustained in the 3-2 win at home to Southampton.
The 29-year-old has appeared from off the bench in the previous three games – seeing a late goal ruled out at Liverpool by VAR last weekend.
Wilson returned to the starting XI for the visit of Mikel Arteta’s Gunners to partner Allan Saint-Maximin in attack.
Speaking to Sky Sports before the game, Bruce said: "He’s been desperate for weeks.
"Just last week when he burst through against Liverpool, it reminded me that he’s ready.
"When you injure a hamstring and you’re all about pace and power, you have to box a bit cleverly and that goes for Allan (Saint-Maximin) too.
"I believe he’s ready – he certainly looks like it.”