A 2-0 victory against the Hammers during last season’s opener provided plenty of optimism for Magpies fans before it all descended into a relegation battle.
Steve Bruce’s side will be hoping the upcoming term fetches better times ahead and that they won’t have to worry about the prospect of dropping into the Championship.
But are the bookmakers backing United to retain their top-flight status once more?
Here are the latest relegation odds for every Premier League club via SkyBet:
13. Wolverhampton Wanderers - 9/2
A new era is about to begin at Wolves following Nuno Espirito Santo’s departure after four years in charge. Photo: Pool
14. Southampton - 9/2
Ralph Hasenhuttl’s men ended the 2020/21 season in awful form but a new campaign represents a new start. Photo: Pool
15. Newcastle United - 11/4
Steve Bruce’s side gave their supporters a relegation scar last term before an excellent end to the season lifted the club up to 12th in the table. Photo: DAVID KLEIN
16. Burnley - 11/4
Burnley finished 17th last term, although did hold an 11-point advantage over the final relegation spot. Photo: Catherine Ivill