Allan Saint-Maximin and Callum Wilson drop out of the side for Joe Willock and Alexander Isak. Wilson scored twice for Newcastle at West Ham but drops back to the bench in favour of Isak, who has scored four goals in his last four appearances.
Saint-Maximin drops out of the squad entirely with a hamstring issue. Newcastle are looking to secure a fifth straight Premier League win and continue their charge for Champions League charge.
The Magpies currently sit 10 points ahead of Brentford in the Premier League table.
NUFC XI to face Brentford: Pope; Trippier, Schar, Botman, Burn; Guimaraes, Longstaff, Willock; Joelinton, Murphy, Isak
NUFC Substitutes: Dubravka, Dummett, Lascelles, Gordon, Wilson, Ritchie, Targett, Manquillo, Anderson
Here are Newcastle United’s absent players this afternoon...
1. Allan Saint-Maximin - hamstring
Saint-Maximin sits out today’s match at Brentford with a hamstring issue. Photo: Alex Pantling
2. Miguel Almiron - thigh
Miguel Almiron is facing a spell on the sidelines after picking up a thigh injury in training. Photo: Michael Regan
3. Jamal Lewis - tactical
Misses out on a place in the squad once again with Paul Dummett preferred. Photo: OLI SCARFF
4. Ryan Fraser - tactical
Ryan Fraser has been frozen out of the first team squad and is training with Newcastle United’s Under-21 squad. Photo: Jan Kruger