Eddie Howe has made just one change from Wednesday night’s 1-0 win over Everton with Joe Willock coming into the starting line-up in place for Jacob Murphy.
Joelinton keeps his place in the side after an injury scare while Bruno Guimaraes also starts less than 48 hours after the birth of his first child.
But several Newcastle players remain sidelined for the match, and we’ll be looking at the reasons why.
NUFC line-up to face Tottenham Hotspur: Pope; Trippier, Schar, Botman, Burn; Guimaraes, Longstaff, Willock; Almiron, Joelinton, Wilson
NUFC subs: Karius, Lascelles, Shelvey, Lewis, Targett, Manquillo, Wood, Fraser, Murphy
1. Allan Saint-Maximin - hamstring
The Newcastle winger has suffered a setback after returning from a hamstring injury off the bench against Brentford earlier this month. Photo: Ian MacNicol
2. Alexander Isak - thigh
Alexander Isak withdrew from international duty with Sweden due to a thigh injury. He remains sidelined following a significant setback. He is not expected to return until after the World Cup. Photo: George Wood
3. Matt Ritchie - calf
The winger suffered a calf injury in training during the international break. He is fighting to be back available before the World Cup break. Photo: Stu Forster
4. Karl Darlow - ankle
The goalkeeper is back in light training as he recovers from an ankle injury. Photo: Gualter Fatia