Captain Jamaal Lascelles and Kieran Trippier came back into the side for Fabian Schar and Emil Krafth.
It’s Trippier’s first start since he went of injured with a broken metatarsal against Aston Villa in February.
The England right-back comes up against his former club, who are fighting to avoid relegation to the Championship this afternoon.
Schar drops to the bench after being brought off in Monday night’s 2-0 win over Arsenal with a head injury.
Ryan Fraser also drops out of the squad entirely after picking up an injury after coming off the bench against the Gunners.
NUFC XI to face Burnley: Dubravka; Trippier, Lascelles, Burn, Targett; Guimaraes, Longstaff, Joelinton; Almiron, Saint-Maximin, Wilson NUFC subs: Darlow, Dummett, Schar, Ritchie, Krafth, Fernandez, Wood, Murphy, Gayle
5. Mark Gillespie - tactical
Misses out with Karl Darlow named on the bench. | Getty Images
7. Isaac Hayden - ineligible
Has recovered from a knee injury but cannot feature as he is not in the 25 man squad. | Getty Images
8. Elliot Anderson - ineligible
Enjoyed a fine loan spell at Bristol Rovers and is part of Newcastle’s squad as an under-21s player but as he returned to Newcastle outside of a transfer window, he cannot play for Newcastle until next season. | Getty Images