Captain Jamaal Lascelles and Kieran Trippier came back into the side for Fabian Schar and Emil Krafth.
It’s Trippier’s first start since he went of injured with a broken metatarsal against Aston Villa in February.
The England right-back comes up against his former club, who are fighting to avoid relegation to the Championship this afternoon.
Schar drops to the bench after being brought off in Monday night’s 2-0 win over Arsenal with a head injury.
Ryan Fraser also drops out of the squad entirely after picking up an injury after coming off the bench against the Gunners.
NUFC XI to face Burnley: Dubravka; Trippier, Lascelles, Burn, Targett; Guimaraes, Longstaff, Joelinton; Almiron, Saint-Maximin, Wilson NUFC subs: Darlow, Dummett, Schar, Ritchie, Krafth, Fernandez, Wood, Murphy, Gayle
9. Jeff Hendrick - ineligible
Has returned from his loan at QPR but is not in Newcastle’s 25 man squad so cannot feature. Photo: Naomi Baker
10. Freddie Woodman - ineligible
Woodman’s loan at AFC Bournemouth has ended following The Cherries’ promotion back to the Premier League. He is ineligible to feature as he is not in Newcastle’s 25 man squad. | Getty Images