All the pre-match talk outside the North East has and will continue to centre around Ronaldo following his sensational return to the Premier League from Juventus.
Steve Bruce’s side, however, will hope to do more than just make up the numbers by claiming a shock result of their own.
But will they face Ronaldo from the start or will he make an appearance from the bench?
Here, we predict Ole Gunnar Solskjaer’s Manchester United starting XI to face the Magpies:
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5. LB: Luke Shaw
Like Maguire, Shaw was in Poland with England on Wednesday. The left-back is at the top of his game at the moment. Photo: Alex Morton
6. CM: Paul Pogba
The French midfielder has provided a hugely impressive five assists in three Premier League games - including four in one game against Leeds. Photo: Catherine Ivill
7. CM: Nemanja Matic
Fred will be banned by FIFA as the international ‘red list’ travel row, continues meaning Matic is in line to step in. Photo: Nathan Stirk
8. CM: Bruno Fernandes
Fernandes netted a hat-trick against Leeds on the opening day of the season as he looks forward to linking up with fellow countryman Cristiano Ronaldo. Photo: Catherine Ivill