All the pre-match talk outside the North East has and will continue to centre around Ronaldo following his sensational return to the Premier League from Juventus.
Steve Bruce’s side, however, will hope to do more than just make up the numbers by claiming a shock result of their own.
But will they face Ronaldo from the start or will he make an appearance from the bench?
Here, we predict Ole Gunnar Solskjaer’s Manchester United starting XI to face the Magpies:
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9. RW: Mason Greenwood
Greenwood, who has played as a number nine and winger already this season, has scored in every game so far against Leeds, Southampton and Wolves. Photo: ADRIAN DENNIS
10. ST: Anthony Martial
Martial to get the nod ahead of Ronaldo? There is, of course, the temptation to start the Portuguese legend but he’s predicted to start on the bench. Photo: FRANCK FIFE
11. LW: Jadon Sancho
Sancho was injured on England duty last week, however the £73m-rated winger was spotted in training for Manchester United ahead of the weekend. Photo: Catherine Ivill