Rangnick has not tasted defeat since being named as Ole Gunnar-Solskjaer’s successor last month.
However, the Red Devil’s have not played since defeating Norwich City, meaning they will travel to St James’s Park having gone 16 days without a game.
In contrast, Eddie Howe’s side have played three games in that period, losing all three at an aggregate score of 11-1.
However, with a packed-out St James’s Park under the lights, great things are expected from the clash on Monday evening - and Newcastle even have some relatively recent success against their opponents.
The Magpies have won two of the last four meetings at St James’s Park, with goals from Matt Ritchie and Matty Longstaff sealing 1-0 wins on those occasions.
Here, we predict the side Eddie Howe will select for Monday’s crucial clash:
Do you agree? Follow us on Twitter @MouthofTynePod and let us know:
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5. LB: Matt Ritchie
Despite being an ever-present before suspension, Jamal Lewis’s emergence meant Ritchie had to settle for a place on the bench for a few weeks. Injury means he is back in the team and will likely have to play in an unfamiliar left-back role again. Photo: Stu Forster
6. RM: Ryan Fraser
Fraser put in one of his better performances in a Newcastle shirt on Sunday and will hope to build on that momentum with another strong performance on Monday. Photo: Robbie Jay Barratt - AMA
7. CM: Joelinton
The Brazilian has been in tremendous form in the middle of the park recently. His strength and physicality gives Newcastle some much needed steel but he will have to be on top-form against a strong Red Devil’s midfield. Photo: Visionhaus
8. CM: Jonjo Shelvey
Howe revealed that he hoped Shelvey would be ‘back soon’ following his omission from the team that faced Manchester City. With eight days to rest and recover between that game and Monday’s fixture, hopefully Shelvey has recovered and can play a role. Photo: Chris Brunskill/Fantasista