Rangnick has not tasted defeat since being named as Ole Gunnar-Solskjaer’s successor last month.
However, the Red Devil’s have not played since defeating Norwich City, meaning they will travel to St James’s Park having gone 16 days without a game.
In contrast, Eddie Howe’s side have played three games in that period, losing all three at an aggregate score of 11-1.
However, with a packed-out St James’s Park under the lights, great things are expected from the clash on Monday evening - and Newcastle even have some relatively recent success against their opponents.
The Magpies have won two of the last four meetings at St James’s Park, with goals from Matt Ritchie and Matty Longstaff sealing 1-0 wins on those occasions.
Here, we predict the side Eddie Howe will select for Monday’s crucial clash:
Do you agree? Follow us on Twitter @MouthofTynePod and let us know:
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9. CM: Joe Willock
A one game suspension to Isaac Hayden may be Willock’s gain on Monday. Newcastle’s only summer signing has disappointed this season but undoubtedly has quality and supporters will be hoping he can start to produce the goods again soon. Photo: Ian MacNicol

10. LM: Allan Saint-Maximin
After starting against Liverpool and Leicester City, Saint-Maximin was rested against Manchester City at the weekend but still found himself on the pitch for the start of the second-half. He has been quiet recently and will be wanting to reach the high standards he has set himself during his time at St James’s Park. Photo: Robbie Jay Barratt - AMA

11. ST: Callum Wilson
Despite being just one booking away from suspension, Wilson is an integral part of Howe’s side and will be a threat to the Manchester United defence. Photo: Stu Forster

