Newcastle Under-21s played in front of a competition record 7,988 fans at The Racecourse Ground which included 285 away fans.
Wrexham took the lead as Sam Dalby finally found the net after Newcastle failed to clear the danger. Dylan Stephenson had a great chance to equalise for The Young Magpies after being played in by Amadou Diallo as Wrexham led 1-0 at the break.
Both teams had chances to grab a second goal in the second half but the score remained 1-0.
In addition to Wrexham, Newcastle Under-21s are in a group alongside Port Vale and Crewe Alexandra. They face Port Vale away on October 10 and Crewe on November 14.
Here are the player ratings from the match...
5. Jordan Hackett - 5
Got stuck in but was prone to overcommitting at times as he had a couple of shaky moments. Photo: Pier Marco Tacca
6. Nathan Carlyon - 6
Tried to make things difficult for Wrexham but guilty of a foul in a dangerous area. A steady display against more experienced opposition. Photo: Bruce Rollinson
7. Jamie Miley - 6
Swept things up well at times in front of the back four and battled well but his passing was inconsistent. | Frank Reid
