The Reds have been embroiled in the European Super League controversy since last Sunday night, and the Magpies will hope to use the unrest at the club to their advantage and pick up a shock win over Jurgen Klopp's side.
Speaking ahead of Saturday's game, Klopp, when asked whether his side were motivated to kick on after dropping more points earlier in the week with a 1-1 draw against Leeds United, claimed: “Definitely, definitely. You can see the intensity the boys put in (against Leeds) – it’s really there.
“We played a lot of good stuff, we could have played even better in moments, I know that – get a bit more clinical and then we will score goals. Newcastle (is) a different challenge, but we’ll face it.”
A win for the Magpies could see them move as high as 13th in the table, while the Reds could move from seventh to fourth in a tightly-packed top half of the table.
Meanwhile, Newcastle will be starting to assess their transfer targets ahead of the summer window opening, as they look to move on some deadwood and bring in some exciting new talent before the start of next season.
Here are today's biggest transfer stories and the latest team news involving Newcastle United and the rest of the Premier League, as the build-up to the weekend action continues:
5. Pundit makes bold Bielsa suggestion
Pundit Jamie O'Hara has controversially claimed that ex-European Super League side Spurs are a "bigger club" than Leeds United, and urged Whites boss Marcelo Bielsa to take the vacant role of Tottenham manager following Jose Mourinho's exit. (talkSPORT) Photo: IAN WALTON
6. Perez fires ESL warning shot
Real Madrid president Florentino Perez has insisted that the European Super League is still "on standby" despite nine of the twelve founding teams, including all six from England, announcing their withdrawal following a mass public outcry. (BBC Sport) Photo: Eric Alonso
7. Blues could snap up Foxes star
Chelsea have been linked with a summer swoop for Leicester City striker Kelechi Iheanacho, as they look to overhaul their goal-shy front-line. Tammy Abraham, Olivier Giroud and Timo Werner have just 15 league goals between them this season. (Mirror) Photo: Pool
8. Whites among favourites to sign Gunners man
Leeds United have been named the close second favourites to sign Arsenal wing-back Ainsley Maitland-Niles, behind Crystal Palace. The £20m-rated ace is currently impressing on a loan spell with West Brom, who continue to battle to avoid relegation. (SkyBet) Photo: NAOMI BAKER