The Magpies will head into the game in decent spirits, after holding Manchester United to a 1-1 draw at St James' Park in their last outing.
When Newcastle last faced the Saints, back in late August, Steve Bruce's side thought they'd snatch a win in stoppage time, after going 2-1 up courtesy of Allan Saint-Maximin, but were pegged back in the 96th minute as England international James Ward-Prowse slotted home the equaliser.
As things stand, the Magpies are 19th in the table and two points from safety, while their next opponents are sitting a little more comfortably up in 13th place.
Speaking ahead of the transfer window opening, Howe gave an insight into the Magpies' plans for the month, and said: "Of course, ideally, you'd want to utilise every day that you have (to do business)
“Certainly, from our perspective, we know we're in a hurry, we're not sat back thinking we've got all the time in the world. That's not where we are in our current position. Every day matters.
“In saying that, you don't control a lot of those factors, the players and the clubs, and sometimes the agents, control the speed of things. We're well aware of what we need to do, but, as I say, doing it is another thing. It's very complex.”
Take a look at today's biggest stories from the Premier League, as the build-up to this weekend's festive football action continues:
5. Barkley could seal Everton return
Chelsea could be set to allow midfielder Ross Barkley to leave on loan, with his former club Everton believed to be interested in bringing the player back on a short term basis. He's made just one league start for the Blues so far this season. (Telegraph) Photo: Alex Pantling
6. Cantwell could quit Canaries
Norwich City are said to be willing to consider selling attacking midfielder Todd Cantwell in the upcoming transfer window. The 23-year-old has fallen out of favour at Carrow Road in recent times, and could be moved on to help fund a rebuild for the Canaries. (The Sun) Photo: Justin Setterfield
7. Top tier sides battle for Dickie
The likes of Leeds United, Burnley, West Ham and Wolves have all been credited with an interest in QPR defender Rob Dickie. The 25-year-old is expected to cost over £10m, and is renowned for his ability to make confident forward runs when in possession. (The Athletic) Photo: Dan Mullan
8. Bayern join Raphinha hunt
Bayern Munich are the latest side to be linked with a move for Leeds United winger Raphinha. The Brazil international has been heavily linked with a move away from Elland Road in recent weeks, after a dazzling opening season and a half for the Whites. (Sport Witness) Photo: Mike Hewitt