A win could see them strengthen their claims on a top flight, top 10 finish, while also plunging the Hammers back into the relegation quagmire.
But who will get the nod, with injuries aplenty, and who will miss out?
Here we take a look at Steve Bruce’s likely starting XI for the visit of David Moyes’ men, as changes are expected.
1. GOALKEEPER: Martin Dubravka
So close to another clean sheet at Bournemouth, the Slovakian will continue between the sticks for United. Photo: Michael Steele
2. RIGHT-BACK: DeAndre Yedlin
The USA international could be set for an NUFC recall with Javier Manquillo struggling and Emil Krafth unlikely to play two 90 minutes in a week after so little football. Photo: Catherine Ivill
3. CENTRE-BACK: Jamaal Lascelles
A slight injury doubt, it would be a surprise if the skipper does not shake it off to lead out his side today. Photo: Pool
4. CENTRE-BACK: Federico Fernandez
The Argentine was brilliant on Wednesday and will be hoping to continue where he left off. Photo: GLYN KIRK