Fabian Schar and Callum Wilson come into the side for Jamaal Lascelles and the injured Chris Wood.
It’s Wilson’s first start since December 27 and he will lead the side out as captain against the Gunners with Lascelles and Kieran Trippier both on the bench.
Newcastle secured Premier League survival last week and will be looking to end their season on a high in their final two games against Arsenal and Burnley. Tonight’s match will be played in front of a packed St James’s Park crowd for the final time this season.
NUFC line-up to face Arsenal: Dubravka; Krafth, Schar, Burn, Targett; Guimaraes, Longstaff, Joelinton; Almiron, Saint-Maximin, Wilson (C)
Subs: Darlow, Dummett, Lascelles, Ritchie, Trippier, Fernandez, Fraser, Murphy, Gayle
Newcastle have 10 players out in total, here are all of the absentees explained...
1. Ryan Fraser - hamstring
The winger made his return from a hamstring injury off the bench against Arsenal but visibly agitated following the full-time whistle as it proved to be his final appearance of the season. Photo: Stu Forster
3. Jonjo Shelvey - calf
The midfielder’s season has been brought to a premature end due to a calf injury. Photo: Ian MacNicol
4. Javier Manquillo - illness
Was likely to miss out with Trippier back available but Eddie Howe confirmed the right-back has contracted chickenpox.