Fabian Schar and Callum Wilson come into the side for Jamaal Lascelles and the injured Chris Wood.
It’s Wilson’s first start since December 27 and he will lead the side out as captain against the Gunners with Lascelles and Kieran Trippier both on the bench.
Newcastle secured Premier League survival last week and will be looking to end their season on a high in their final two games against Arsenal and Burnley. Tonight’s match will be played in front of a packed St James’s Park crowd for the final time this season.
NUFC line-up to face Arsenal: Dubravka; Krafth, Schar, Burn, Targett; Guimaraes, Longstaff, Joelinton; Almiron, Saint-Maximin, Wilson (C)
Subs: Darlow, Dummett, Lascelles, Ritchie, Trippier, Fernandez, Fraser, Murphy, Gayle
Newcastle have 10 players out in total, here are all of the absentees explained...
5. Mark Gillespie - tactical
Misses out with Karl Darlow named on the bench. | Getty Images
7. Isaac Hayden - ineligible
Has recovered from a knee injury but cannot feature as he is not in the 25 man squad. | Getty Images
8. Elliot Anderson - ineligible
Enjoyed a fine loan spell at Bristol Rovers and is part of Newcastle’s squad as an under-21s player but as he returned to Newcastle outside of a transfer window, he cannot play for Newcastle until next season. | Getty Images