The Newcastle United winger set up Callum Wilson’s winner against Everton at St James’s Park last weekend.
However, Fraser misses out at St Mary’s Stadium because of a hamstring problem. Matty Longstaff replaces him on the bench.
The 26-year-old joined the club in the summer as a free agent after leaving Bournemouth when his contract expired.
Fraser is also set to miss Scotland’s upcoming fixtures against Serbia, Slovakia and Israel.